Aspartateand glutamate act as neurotransmitters in the brain by facilitating thetransmission of information from neuron to neuron. Too much aspartateor glutamate in the brain kills certain neurons by allowing the influxof too much calcium into the cells. This influx triggers excessiveamounts of free radicals, which kill the cells. The neural cell damagethat can be caused by excessive aspartate and glutamate is why they arereferred to as "excitotoxins." They "excite" or stimulate the neuralcells to death.
Aspartic acid is an amino acid. Taken in its free form (unbound toproteins) it significantly raises the blood plasma level of aspartateand glutamate. The excess aspartate and glutamate in the blood plasmashortly after ingesting aspartame or products with free glutamic acid(glutamate precursor) leads to a high level of those neurotransmittersin certain areas of the brain.
The blood brain barrier (BBB), which normally protects the brain fromexcess glutamate and aspartate as well as toxins, 1) is not fullydeveloped during childhood, 2) does not fully protect all areas of thebrain, 3) is damaged by numerous chronic and acute conditions, and 4)allows seepage of excess glutamate and aspartate into the brain evenwhen intact.
The excess glutamate and aspartate slowly begin to destroy neurons.The large majority (75 percent or more) of neural cells in a particulararea of the brain are killed before any clinical symptoms of a chronicillness are noticed. A few of the many chronic illnesses that have beenshown to be contributed to by long-term exposure to excitatory aminoacid damage include:
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http://articles.mercola.com/sites/articles/archive/2011/11/06/aspartame-most-dangerous-substance-added-to-food.aspx
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